From listmaster animalgenome.org Tlistmaster Sep 7 10:09:49 2023
From: "Marcel Amills" <marcel.amillsuab.cat>
To: Members of AnGenMap <angenmapanimalgenome.org>
Subject: PhD position in goat genomics available at CRAG (Barcelona,
Spain)
Date: Thu, 07 Sep 2023 10:09:49 -0500
Dear colleagues
The Department of Animal Genetics of the Centre for Research in
Agricultural Genomics (CRAG, Barcelona, Spain) has opened a PhD position
funded for 4 years with an FPI grant from the Spanish Ministry of Science
and Innovation. The selected candidate would carry out the doctoral thesis
under the supervision of Dr. Marcel Amills and within the scope of the
project "Transcriptomic analysis of lactation and fine mapping of
polymorphisms with causal effects on dairy phenotypes and viability in the
Murciano-Granadina breed" (CAPRAGENE, PID2022-136834OB-I00). The deadline
to apply online is September 30. A very detailed explanation of the
requirements and the mechanism for making the application can be found in
the web address:
https://recruitment.cragenomics.es/...l-genomics
Applications should be made through the website indicated above.
Below, I summary of the PhD project can be found:
Thank you very much,
Marcel Amills
Full professor
Department of Animal Genetics
Centre for Research in Agricultural Genomics
Bellaterra 08193 (Barcelona, Spain)
SUMMARY OF THE PROJECT: Copy number variation (CNV) in the caprine genome
can have important consequences on phenotypes of economic interest. A
compelling example is provided by the 11.7 kb deletion in goat chromosome
1q43 that triggers intersex and absence of horns in goats by modifying the
expression of the FOXL2 and PISRT1 genes. It has also been described that a
large deletion in the CSN1S1 gene suppresses the synthesis of said milk
protein. In addition, a complex CNV aggregation in the agouti protein gene
determines the pigmentation patterns of various goat breeds. The objective
of the doctoral thesis will be to characterize CNVs (duplications and
deletions) segregating in the genomes of 100 males of the Murciano-
Granadina breed. CNV detection based on next generation sequencing data may
be carried out by various strategies (e.g. read pair, split read and read
depth) or a combination thereof. CNVs containing genes potentially related
to performance and milk composition will be further characterized and
genotyped by quantitative PCR in a population of 1,500 goats with
phenotypic records to determine the existence of associations with
productive traits. Functional tests will be performed to explore the
causality of such associations.
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