QTLdb: entrichment tests

Release 58
(Dec 29, 2025)

Whole genome analysis for QTL/association enrichment

Running...

Version: Enrich S: beta v0.8

Search:	to limit the list of your trait choices:
	(optional) focus on chromosome with Mb windows across its length

Data:

Number of disease traits:	21
Number of QTL / associations found:	7,973
Number of chromosomes where QTL / associations are found:	30

Chi-squared (χ²) test: are disease traits over-represented on some chromosomes?

Chromosomes	Total χ²	df	p-values	FDR ^*	Size of χ²
Chromosome X	4889.93589	29	9e-41	1.000000e-40
Chromosome 1	934.78224	29	5.064479e-178	3.798359e-177
Chromosome 2	900.72066	29	7.652e-171	4.591200e-170
Chromosome 3	70.01316	29	3.019637e-05	3.123762e-05
Chromosome 4	2277.31770	29	9e-41	1.000000e-40
Chromosome 5	1210.39233	29	2.33645e-236	3.504675e-235
Chromosome 6	1575458.98587	29	9e-41	1.000000e-40
Chromosome 7	2468.99121	29	9e-41	1.000000e-40
Chromosome 8	2581.99557	29	9e-41	1.000000e-40
Chromosome 9	2468.99121	29	9e-41	1.000000e-40
Chromosome 10	709.62675	29	9.656906e-131	4.828453e-130
Chromosome 11	2331.29148	29	9e-41	1.000000e-40
Chromosome 12	3059.29848	29	9e-41	1.000000e-40
Chromosome 13	2581.99557	29	9e-41	1.000000e-40
Chromosome 14	1152.42582	29	4.662225e-224	4.662225e-223
Chromosome 15	2067.74442	29	9e-41	1.000000e-40
Chromosome 16	272.88576	29	1.765412e-41	7.566051e-41
Chromosome 17	2697.52854	29	9e-41	1.000000e-40
Chromosome 18	2468.99121	29	9e-41	1.000000e-40
Chromosome 19	1351.17906	29	2.761848e-266	8.285544e-265
Chromosome 20	195.70236	29	1.192944e-26	1.278154e-26
Chromosome 21	2250.56790	29	9e-41	1.000000e-40
Chromosome 22	2441.13513	29	9e-41	1.000000e-40
Chromosome 23	40.95609	29	0.0694763	6.947630e-02
Chromosome 24	3921.20190	29	9e-41	1.000000e-40
Chromosome 25	2905.79541	29	9e-41	1.000000e-40
Chromosome 26	3313.12107	29	9e-41	1.000000e-40
Chromosome 27	4618.61358	29	9e-41	1.000000e-40
Chromosome 28	2845.50042	29	9e-41	1.000000e-40
Chromosome 29	3090.47319	29	9e-41	1.000000e-40

Chi-squared (χ²) test: Which of the 21 disease traits are over-represented in the QTLdb

Traits	Total χ²	df	p-values	FDR ^*	Size of χ²
Bovine coronavirus susceptibility	384.5058	20	3.322205e-69	1.395326e-68
Bovine leukemia virus susceptibility	710.76834	20	1.164779e-137	1.223018e-136
Bovine respiratory disease susceptibility	1514.4639	20	9e-41	2.100000e-40
Bovine spongiform encephalopathy susceptibility	138.16488	20	1.127200e-19	1.690800e-19
Bovine tuberculosis susceptibility	1837.30093	20	9e-41	2.100000e-40
Bovine viral diarrhea virus susceptibility	450.47434	20	6.491789e-83	3.408189e-82
Cholesterol deficiency	83.81913	20	8.741892e-10	1.147373e-09
Cystic ovaries	139.36698	20	6.672489e-20	1.077864e-19
Dwarfism	32.78388	20	0.03562908	3.562908e-02
Endometritis	64.48966	20	1.407003e-06	1.555109e-06
Epidermolysis bullosa	87.58887	20	1.950859e-10	2.731203e-10
Foot-and-mouth disease susceptibility	471.12801	20	3.176233e-87	2.223363e-86
General disease susceptibility	78.40973	20	7.297255e-09	9.014256e-09
Infectious bovine keratoconjunctivitis susceptibility	205.09341	20	1.102862e-32	2.105464e-32
Ketosis	1033.72028	20	2.504387e-206	5.259213e-205
M. paratuberculosis susceptibility	2035.6746	20	9e-41	2.100000e-40
Marfan syndrome-like disease	70.52892	20	1.49259e-07	1.741355e-07
Metritis	241.66236	20	5.455605e-40	1.145677e-39
Milk fever	1533.95761	20	9e-41	2.100000e-40
Percentage decrease in body weight up to day 150 after challenge	64.17254	20	1.579929e-06	1.658925e-06
Rabies antibody titer	164.10417	20	1.207876e-24	2.113783e-24

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data		Chi'Square Test			Fisher's Exact Test
Number of chrom.:	30	χ²	=	1637578.159980
Number of traits:	21	df	=	580
Number of QTLs:	7,973	p-value	=	0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.